Misoprostol 200 mcg

 What is misoprostol?

Misoprostol: Versatile Medication for Stomach Ulcers, and It is used to induce labour, treat manage abortion and uterine rupture.

Misoprostol 200 mcg Tablet: the safe basis for your solution. This medicine acts on the uterus, increasing its contractions to facilitate abortion or manage postpartum hemorrhage. Provides a safe and effective way to terminate pregnancies. Additionally, it plays an important role in preventing excessive bleeding after delivery, ensuring postpartum health. It is best to take Misoprost 200 Tablet with food or as advised by your healthcare provider. Misoprostol is a synthetic prostaglandin medication known for its diverse applications in the field of healthcare. It serves as a valuable tool in preventing and treating stomach and duodenal ulcers. When taken orally, it effectively shields individuals using nonsteroidal anti-inflammatory drugs (NSAIDs) from the development of gastric ulcers.

In the realm of reproductive health, Misoprostol plays a crucial role. It can be used independently or in conjunction with mifepristone or methotrexate to induce abortion, whose success rates ranging from will be in 2023. 89% to 97%. For labor induction or abortion, Misoprostol can be administered orally, dissolved in the mouth, or placed in the vagina, offering flexibility in its usage. In cases of postpartum bleeding, this medication can even be administered rectally.

Misoprostol falls under Pregnancy Category in 2023 X, which indicates potential harm to the fetus if taken during pregnancy. Rarely, uterine rupture may occur as a side effect. This drug, a synthetic prostaglandin E1 (PGE1) analog, was developed in 1973 and is included in the World Health Organization List of Essential Medicines. It is easily available as a generic medicine, 

 In conclusion, misoprostol has versatile applications in preventing ulcers, inducing labor, facilitating abortion and managing postpartum hemorrhage. Canada designates it as Prescription Only (℞), as does the UK (POM, or Prescription Only Medicine). In the United States, it is also ℞-only. Within the European Union, misoprostol falls under the RX category only. in 2023 Misoprostol boasts impressive Pharmacokinetic properties. It is extensively absorbed, with 85–91% of the active metabolite, misoprostol acid, binding to proteins. The liver plays an important role in its metabolism, converting it into misoprostol acid. The drug has a short elimination half-life, typically 24 to 42 minutes, with excretion primarily via urine (84%).

Chemistry of Misoprostol: Its Structure

Misoprostol, a drug of vital medical importance, is a water soluble and viscous liquid. Its chemical description is quite complex: (±)methyl 11α,1 6-dihydroxy 16-methyl-9h-oxoprost-13E-en-1-oate. This chemical structure underlies its diverse medicinal actions.

There are two common strengths of these tablets available: 100 mcg and 200 mcg. Of course, each tablet contains the same active ingredient, misoprostol. However, these also contain officially inactive ingredients that differ in composition and function from tablets. Hydrogenated Castor Oil: This ingredient can be used as an excipient to improve the physical properties of the tablet, such as its appearance and stability. Hypromellose: Also known as hydroxypropyl methylcellulose, hypromellose is a key ingredient in tablet coatings. This can provide controlled drug release and help protect the active ingredient.
Microcrystalline cellulose: It is a common pharmaceutical excipient that is used for its binding and dissolution properties. This helps keep the tablet together and ensures that it breaks properly when swallowed. Sodium starch glycolate: This ingredient is often added to tablets as a superdisintegrant. This aids in the rapid disintegration of the tablet, ensuring that the active ingredient is efficiently released and absorbed into the digestive tract.

Misoprostiol Uses:

Used to treat early pregnancy loss, complete miscarriage, or remission, miscarriage in the first trimester of pregnancy.

First Trimester of Pregnancy:

Early Pregnancy Loss: The recommended dose is 800 mcg once intravenously. If there is no response to the first dose a second dose may be given, but this second dose should not be given earlier than 4 hours after the first dose and usually within 6 days.

Incomplete abortion: For cases of incomplete abortion, the recommended dosage is 600 mcg orally once daily.

Missed abortion: In case of missed abortion, there are two recommended methods of administration:

800 mcg once intravenously.
600 mcg once sublingually.
Additionally, the dose may be repeated every 4 hours for 3 additional doses.

More information Pain medications should be made available to manage any discomfort during the abortion procedure.

For patients who are Rh(D) negative and desensitized, Rh(D)-immune globulin should be given within 72 hours of administration of the initial dose.

Follow-up treatment should be scheduled within 6 to 14 days to ensure that complete expulsion of the pregnancy has occurred.

In cases where the recommended treatment fails, patients may opt for expectant management or suction curettage as alternative options.

Side effects

Misoprostol: The medicine may also cause some unwanted effects. It is important to note that not all of these side effects may occur, but if they occur, they may require medical attention. Please consult your healthcare provider if you experience any of the following side effects 

Rare side effects (less than 1%)

Cramps – less than 1%

Heavy bleeding – less than 1%

Painful menstruation – less than 1%

Side Effects with Incidence

• Bladder pain - less than 7% 
• Bloody nose - less than 2%
• Bloody or black, tarry stools - less than 4%
• Bloody or cloudy urine - less than 1%
• Blurred vision - less than 2%
• Body aches or pain - less than 9%
• Chest pain - less than 11%
• Chills - less than 1%
• Confusion - less than 3%
• Constipation - less than 1%
• Cough - less than 1%
• Difficult, burning, or painful urination - less than 0.1%
• Difficulty with breathing - less than 2%
• Difficulty with moving - less than 1%
• Difficulty with swallowing - less than 6%
• Dizziness - less than 3%
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position - less than 2%
• Ear congestion - less than 1%
• Feeling unusually cold - less than 1%
• Fever - less than 9%
• Frequent urge to urinate - less than 1% 
• Headache - less than 1%
• Hives, itching, or skin rash - less than 1%
• Loss of voice - less than 3%
• Lower back or side pain - less than 1%
• Muscle pain or stiffness - less than 1%
• Nasal congestion - less than 2%
• Nervousness - less than 1%
• Pain in the joints - less than 1%
• Pale skin - less than 1%
• Pounding in the ears - less than 1%
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Runny nose - less than 1%
• Severe stomach pain - less than 4%
• Shivering - less than 1%
• Slow or fast heartbeat - less than 1%
• Sneezing - less than 2%
• Sore throat - less than 1%
• Sweating - less than 1%
• Tightness in the chest - less than 1%
• Troubled breathing with exertion - less than 1%
• Unusual bleeding or bruising - less than 1%
• Unusual tiredness or weakness - less than 2%
• Vomiting of blood or material that looks like coffee grounds - less than 12%

Common Side Effects (1% to 10%):

• Abdominal or stomach pain
• Diarrhea

Less Common Side Effects (1% to 10%):

• Acid or sour stomach
• Belching
• Bloated feeling
• Excess air or gas in the stomach or intestines
• Full feeling
• Heartburn
• Indigestion
• Passing gas
• Stomach discomfort or upset

Misoprostol Warnings

1. Precautions for people with heart disease: Use caution when giving misoprostol to 2. people with pre-existing heart disease.

2. Keep misoprostol out of the reach of children.

3. Pregnancy: Misoprostol should not be used if you are pregnant or planning to become pregnant. It can harm the fetus and cause serious complications.

 Misoprostol Price: 2023 

US - $100 - location 1901 S I-35 Frontage Rd, Austin, TX 78704, United States

UK - $99   location  2a, Raleigh Gardens, Brixton Hill, London SW2 1AB, United Kingdom

Italy - $ 120  -  location Aventino Medical Group, Via Sant'Alberto Magno, 4, 00153 Roma RM, Italy

Germany - $110   - location Konrad-Wolf-Straße, Hinterhof 12-12A, 13055 Berlin, Germany

France - $ 99   - location